N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-norleucine
Fmoc-L-Norleucine
CAS: 77284-32-3
Molecular Formula: C21H23NO4
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-norleucine - Names and Identifiers
| Name | Fmoc-L-Norleucine |
| Synonyms | Fmoc-Nle-OH Fmoc-L-Norleucine (S)-2-(FMOC-AMINO)CAPROIC ACID (S)-2-(FMOC-AMINO)HEXANOIC ACID (S)-N-ALPHA-FMOC-2-AMINOHEXANOIC ACID (9H-Fluoren-9-yl)MethOxy]Carbonyl L-Nle-OH N-alpha-9-Fluorenylmethoxycarbonyl-L-norleucine N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-norleucine (S)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-HEXANOIC ACID (2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoate N-(9-Fluorenylmethoxycarbonyl)-Lnorleucine,Fmoc-L-norleucine |
| CAS | 77284-32-3 |
| InChI | InChI=1/C21H23NO4/c1-2-3-12-19(20(23)24)22-21(25)26-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,2-3,12-13H2,1H3,(H,22,25)(H,23,24)/p-1/t19-/m1/s1 |
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-norleucine - Physico-chemical Properties
| Molecular Formula | C21H23NO4 |
| Molar Mass | 353.41 |
| Density | 1.209±0.06 g/cm3(Predicted) |
| Melting Point | 141-144°C(lit.) |
| Boling Point | 565.6±33.0 °C(Predicted) |
| Specific Rotation(α) | -18.5 º (C=1 IN DMF) |
| Flash Point | 295.9°C |
| Vapor Presure | 1.25E-13mmHg at 25°C |
| Appearance | Crystalline Powder |
| Color | White to off-white |
| BRN | 5305164 |
| pKa | 3.91±0.21(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD00037537 |
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-norleucine - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 2924 29 70 |
| Hazard Class | IRRITANT |
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-norleucine - Introduction
N-Fmoc-L-norleucine (Fmoc-L-Norleucine) is an amino acid derivative. It has the following properties:
1. Appearance: Fmoc-L-norleucine is a white to yellowish solid.
2. Solubility: It dissolves well in some organic solvents (such as methanol, dichloromethane and dimethylthionamide).
3. Stability: The compound can be stored stably for a long time at room temperature.
Fmoc-L-norleucine has many applications in biochemistry and organic synthesis:
1. Peptide synthesis: It is often used in solid phase synthesis and liquid phase synthesis as one of the amino acid units for constructing polypeptide chains.
2. protein research: Fmoc-L-norleucine can be used to study protein structure and function, and related genetic engineering research.
3. Drug development: The compound can be used as a starting material for the design and synthesis of drug candidates.
The preparation method of Fmoc-L-norleucine is generally realized by organic synthesis. A common synthetic route is the reaction of norleucine with Fmoc-carbamate under basic conditions.
Regarding safety information, Fmoc-L-norleucine is relatively safe under general operating conditions, but the following matters still need to be noted:
1. Avoid contact with skin and eyes: Wear appropriate personal protective equipment, such as lab gloves and goggles.
2. Avoid inhalation or ingestion: Good ventilation should be ensured during operation to avoid dust generation. If inhaled or ingested, seek medical attention immediately.
3. storage and handling: Fmoc-L-norleucine should be stored in a dry, cool place, away from combustibles. Disposal of waste shall comply with relevant environmental regulations.
1. Appearance: Fmoc-L-norleucine is a white to yellowish solid.
2. Solubility: It dissolves well in some organic solvents (such as methanol, dichloromethane and dimethylthionamide).
3. Stability: The compound can be stored stably for a long time at room temperature.
Fmoc-L-norleucine has many applications in biochemistry and organic synthesis:
1. Peptide synthesis: It is often used in solid phase synthesis and liquid phase synthesis as one of the amino acid units for constructing polypeptide chains.
2. protein research: Fmoc-L-norleucine can be used to study protein structure and function, and related genetic engineering research.
3. Drug development: The compound can be used as a starting material for the design and synthesis of drug candidates.
The preparation method of Fmoc-L-norleucine is generally realized by organic synthesis. A common synthetic route is the reaction of norleucine with Fmoc-carbamate under basic conditions.
Regarding safety information, Fmoc-L-norleucine is relatively safe under general operating conditions, but the following matters still need to be noted:
1. Avoid contact with skin and eyes: Wear appropriate personal protective equipment, such as lab gloves and goggles.
2. Avoid inhalation or ingestion: Good ventilation should be ensured during operation to avoid dust generation. If inhaled or ingested, seek medical attention immediately.
3. storage and handling: Fmoc-L-norleucine should be stored in a dry, cool place, away from combustibles. Disposal of waste shall comply with relevant environmental regulations.
Last Update：2024-04-09 20:02:46
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